Activation of Heat Shock Proteins by Nanocurcumin to Prevent Neurodegenerative Diseases
نویسندگان
چکیده
منابع مشابه
Heat shock proteins in autoimmune diseases.
Heat shock proteins (hsp's) are among the most conserved proteins in evolution. They have been identified as important pathogen-related antigens as well as autoantigens suitable for construction of novel vaccines. The high evolutionary homology of hsp's has raised the question about the safety of such vaccines. Experimental and clinical observations have confirmed that hsp proteins are involved...
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There are numerous human diseases that are associated with protein misfolding and the formation of toxic protein aggregates. Activating the heat shock response (HSR)--and thus generally restoring the disturbed protein homeostasis associated with such diseases--has often been suggested as a therapeutic strategy. However, most data on activating the HSR or its downstream targets in mouse models o...
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With the assistance of proteins called chaperones, newly translated proteins fold into the three-dimensional shapes that are critical to their function. When proteins fold abnormally or become unstable, the consequences can be dire for cells, particularly neurons, which are exquisitely sensitive to the accumulation of misfolded proteins. Many neurodegenerative diseases, like Parkinson’s and Cre...
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As all biologists appreciate, there is constant interaction between life and the environment, and temperature plays a critical role. It establishes distribution limits, it affects rates of function as well as the survival of organisms. Notoriously sensitive to temperature is plant growth. Critical steps in plant life such as germination, flowering and breaking of dormancy can be manipulated by ...
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ژورنال
عنوان ژورنال: Brain Disorders & Therapy
سال: 2014
ISSN: 2168-975X
DOI: 10.4172/2168-975x.1000139